Distinguishing Human Cell Types Based On Housekeeping Gene Signatures

Expression Profiling of Microarray Gene Signatures in Acute and Chronic Myeloid Leukaemia in Human Bone Marrow

Background Classification of cancer subtypes by means of microarray signatures is becoming increasingly difficult to ignore as a potential to transform pathological diagnosis nonetheless, measurement of Indicator genes in routine practice appears to be arduous. In a preceding published study, we utilized real-time PCR measurement of Indicator genes in acute lymphoid leukaemia (ALL) and acute m...

Gene Ontology Signatures for Immune Cell-Types Inferred by Gene Expression Analysis

Distinguishing between Two Types of Gene Action in Quantitative Inheritance.

MONG the widely divergent results obtained from “quantitative A character” crosses one common type is characterized by (a) F1 mean approaching that of the smaller parent strain and (b) positive skewness in the frequency distribution of Fz measurements. Among many examples might be cited crosses involving differences of corolla tube length in tobacco (EAST 1913; SMITH 1937), fruit size in squash...

On the nature of human housekeeping genes.

Using a collection of expressed sequence tag (EST) data, we re-evaluated the correlation of tissue specificity with genomic structure, phyletic age, evolutionary rate and promoter architecture of human genes. We found that housekeeping genes are less compact and older than tissue-specific genes, and they evolve more slowly in terms of both coding and core promoter sequences. Housekeeping genes ...

Predicting Housekeeping Genes Based on Fourier Analysis

Housekeeping genes (HKGs) generally have fundamental functions in basic biochemical processes in organisms, and usually have relatively steady expression levels across various tissues. They play an important role in the normalization of microarray technology. Using Fourier analysis we transformed gene expression time-series from a Hela cell cycle gene expression dataset into Fourier spectra, an...